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Review | Regular issue | Vol 96, No. 1, 2018, pp.3-41
Published online, 15th December, 2017
DOI: 10.3987/REV-17-873
Total Syntheses of Liphagal: A Potent and Selective Phosphoinositide 3-Kinase α (PI3Kα) Inhibitor from the Marine Sponge Aka coralliphaga

Koichi Narita and Tadashi Katoh*

*Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, 4-4-1 Komatsushima, Aoba-ku, Sendai 981-8558, Japan


Liphagal, isolated from the marine sponge Aka coralliphaga, exhibits a potent and selective inhibitory activity against phosphoinositide 3-kinase α (PI3Kα). This marine natural product has attracted significant attention because of its potential as a promising candidate or new lead for the development of novel molecular targeted anticancer agents. In this review, the reported total syntheses of liphagal are presented with a particular focus on the methodologies and strategies employed.