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Paper | Regular issue | Vol 96, No. 1, 2018, pp.50-66
Published online, 12th December, 2017
DOI: 10.3987/COM-17-13819
A Facile Synthesis of Novel Heterocyclic Compounds with Anticipated Antibacterial Activities Based on Coumarin Moiety

Asmaa Kamal Mourad,* Fathia Korany Mohamed, and Ahmed Yousef Soliman

*Department of Chemistry, Faculty of Science, Fayoum University, 63514 Fayoum, Egypt


A novel series of coumarin derivatives has been disclosed by allowing 2-aminonicotinonitrile derivative 1 to undergo alkylation, diazotization, and condensation reactions. Moreover, different reagents, such as thiourea, phenyl isothiocyanate, carbon disulfide, ethylenediamine, and hydroxylamine hydrochloride, have been exploited to synthesize more coumarin derivatives, aiming to increase the synthetic potential of coumarin and study the antibacterial activities of the newly synthesized compounds.