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Short Paper | Regular issue | Vol 96, No. 1, 2018, pp.127-136
Published online, 28th November, 2017
DOI: 10.3987/COM-17-13814
Synthesis of Dibromo Compounds Containing 2,6-Dioxabicyclo[3.1.1]heptane Similar to Core Moiety of Thromboxane A2

Yoshihiko Nokura, Atsuo Nakazaki, and Toshio Nishikawa*

*Graduate School of Bioagricultural Sciences, Nagoya University, Chikusa, Nagoya 464-8601, Japan


Thromboxane A2, a potent platelet aggregation factor, contains a labile 2,6-dioxabicyclo[3.1.1]heptane as the core moiety. Dibromo compounds with a similar core structure were synthesized by the cyclization of tribromides derived from D-glucal.