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Review | Regular issue | Vol 96, No. 3, 2018, pp.381-424
Published online, 6th February, 2018
DOI: 10.3987/REV-17-872
4-Hydroxy-6-methyl-2-pyrone: A Versatile Synthon in the Synthesis of Heterocyclic Scaffolds via Multicomponent Reactions

Ghodsi Mohammadi Ziarani,* Razieh Moradi, Marziyeh Zandiyeh, and Negar Lashgari*

*Department of Chemistry, Alzahra University, Tehran, Iran

Abstract

4-Hydroxy-6-methyl-2-pyrone has been utilized in the synthesis of various heterocyclic compounds. It is a potential 1,3-dicarbonyl compound with diverse synthetic applications that have been extensively investigated. There is a wide range of multicomponent reactions that include 4-hydroxy-6-methyl-2-pyrone in the synthesis of heterocyclic compounds. This review highlights the advances in the use of this compound as starting material in the synthesis of various organic compounds.