Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Review | Regular issue | Vol 96, No. 3, 2018, pp.381-424
Published online, 6th February, 2018
DOI: 10.3987/REV-17-872
4-Hydroxy-6-methyl-2-pyrone: A Versatile Synthon in the Synthesis of Heterocyclic Scaffolds via Multicomponent Reactions

Ghodsi Mohammadi Ziarani,* Razieh Moradi, Marziyeh Zandiyeh, and Negar Lashgari*

*Department of Chemistry, Alzahra University, Tehran, Iran


4-Hydroxy-6-methyl-2-pyrone has been utilized in the synthesis of various heterocyclic compounds. It is a potential 1,3-dicarbonyl compound with diverse synthetic applications that have been extensively investigated. There is a wide range of multicomponent reactions that include 4-hydroxy-6-methyl-2-pyrone in the synthesis of heterocyclic compounds. This review highlights the advances in the use of this compound as starting material in the synthesis of various organic compounds.