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Short Paper | Regular issue | Vol 94, No. 10, 2017, pp.1940-1957
Published online, 9th August, 2017
DOI: 10.3987/COM-17-13777
AgNTf2-Mediated Arylation of Bromopyrroloindolines

Soichiro Sato, Azusa Hirayama, Tohma Adachi, Daichi Kawauchi, Hirofumi Ueda, and Hidetoshi Tokuyama*

*Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3 Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan


The silver(I)-mediated arylation of bromopyrroloindolines was developed. The selection of silver salts was crucial to obtain arylated compounds in high yields. Among the various tested silver(I) salts, AgNTf2 was the most effective agent for arylation. Reactions using various electron-rich aromatic compounds revealed that the developed conditions are suitable for the arylation of a broad range of aromatic compounds, including benzene derivatives, furan, thiophene, and pyrrole.