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Short Paper | Regular issue | Vol 94, No. 10, 2017, pp.1909-1922
Published online, 24th August, 2017
DOI: 10.3987/COM-17-13769
Selenium Dioxide Mediated Benzylic sp3 C-H Oxidation in Acetic Acid: Synthesis of Lophine Derivatives from α-Methylene Ketones via a Domino Multicomponent Reaction

Vineet Jeena* and Mncedisi Mazibuko

*School of Chemistry and Physics, University of KwaZulu-Natal, Scottsville, Pietermaritzburg, 3209, South Africa

Abstract

We report a selenium dioxide/acetic acid catalysed one-pot conversion of α-methylene ketones to 1,2-diaryldiketones as a key step to successfully access lophine derivatives in a domino multicomponent reaction.