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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Short Paper | Regular issue | Vol 94, No. 8, 2017, pp.1582-1588
Published online, 23rd June, 2017
Published online, 23rd June, 2017
DOI: 10.3987/COM-17-13739
■ Three New Isoflavones from the Root of Pueraria lobata and their Bioactivities
Feng-Mei Zhang, Jing Li, Qi-Li Mi, Shi-Yun Tang, Ye-Kun Yang, Jian-Hua Chen, Chun-Bo Liu, Qin-Peng Shen, Zhi-Hua Liu, Guang-Yu Yang, Qiu-Fen Hu, Zhong-Tao Ding,* and Xue-Mei Li*
*School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Abstract
Three new isoflavones, 4′-hydroxy-6-methoxy-7methyl-isoflavone (1), 4′,6-dihydroxy-7-methylisoflavone (2), and 4′-hydroxy-7-hydroxymethyl-6- methoxyisoflavone (3), together with two known isoflavones (4 and 5), were isolated from the root of Pueraria lobata. Their structures were elucidated by spectroscopic methods, including extensive 1D- and 2D NMR techniques. Compounds 1-5 were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compounds 1 and 2 exhibited comparable anti-TMV activities with inhibition rates of 34.2 and 33.5%. The other compounds also showed potential anti-TMV activities with inhibition rates in the range of 21.8-25.6%, respectively. The cytotoxicities of compounds 1-5 against five human tumor cell lines (NB4, A549, SHSY5Y, PC3, and MCF7) were also tested. The results revealed that compounds 1-5 showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 3.9-9.2 μM.
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