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Short Paper | Regular issue | Vol 94, No. 9, 2017, pp.1736-1747
Published online, 14th July, 2017
DOI: 10.3987/COM-17-13724
Catalyst-Free Multicomponent Formation of Novel Acylpyrrole-Containing 6-Iminohexahydro-1H-pyrido[1,2-a]pyrimidine Derivatives

Xiaohua Wu, Zheng Zhao, Yuwei Song, and Cheng Guo*

*College of Chemistry and Molecular Engineering, Nanjing Tech University, 30 Puzhu South Road, Jiangsu, Nanjing, 211816, China

Abstract

A simple and green synthesis of acylpyrrole-containing 6-iminohexahydro-1H-pyrido[1,2-a]pyrimidine derivatives were successfully prepared via four-component reaction of 1,1-bis(methylthio)-2-nitroethene, propane-1,3-diamine, 3-(1-methyl-1H-pyrrol-2-yl)-3-oxopropanenitrile and aromatic aldehydes in ethanol under microwave irradiation. This method offers several significant advantages, including green solvent, avoidance of catalysts, high-speed reaction, outstanding selectivity, tremendous substrate diversity and no column chromatographic purification.