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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Short Paper | Regular issue | Vol 94, No. 8, 2017, pp.1573-1581
Published online, 23rd June, 2017
Published online, 23rd June, 2017
DOI: 10.3987/COM-17-13722
■ Four New Cantharidin Derivatives from the Chinese Blister Beetles, Mylabris phalerata
Yuan-Yuan Deng, Wei Zhang, Xue-Ping Lei, Dong-Mei Zhang, Jun He, Lei Wang,* and Wen-Cai Ye*
*JNU-HKUST Joint Laboratory for Neuroscience & Innovative Drug Research, Jinan University, Guangzhou 510630, China
Abstract
Four new cantharidin derivatives, cantharacidines A-D (1-4) were isolated from the Chinese blister beetles Mylabris phalerata. Their structures with absolute configurations were elucidated by means of NMR spectroscopy, single-crystal X-ray diffraction and electronic circular dichroism (ECD) spectral analyses. Compounds 1-3 are the first examples of natural cantharimide-carboxylic acid adducts. The inhibitory effects of compounds 1-4 on the viability of three cancer cell lines (HepG2, MDA-MB-231 and A549 cells) were evaluated by the MTT assay.
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