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Short Paper | Regular issue | Vol 94, No. 9, 2017, pp.1728-1735
Published online, 6th July, 2017
DOI: 10.3987/COM-17-13704
A Cytotoxic Pyranonaphthoquinone from Cultured Lichen Mycobionts of Haematomma sp.

Yukiko Takenaka, Yoshiyuki Mizushina, Nobuo Hamada, and Takao Tanahashi*

*Kobe Pharmaceutical University, 4-19-1 Motoyamakita-machi, Higashinada-ku, Kobe 658-8558, Japan

Abstract

Spore-derived mycobionts of the lichen Haematomma sp. were cultivated on malt-yeast extract medium supplemented with 10% sucrose to produce a new pyranonaphthoquinone, 4, as well as two known compounds (-)-usnic acid (2) and 5-deoxy-7-methylbostrycoidin (3). The structure of 4 was determined by spectroscopic methods. The inhibitory activities of 3, 4, and 68 against mammalian DNA polymerases (pols) and cytotoxic effects against a HeLa human cervical cancer cell line were also evaluated. Compound 4 showed the strongest mammalian pol inhibitory activity and cytotoxicity (ID50 = 6.7 μM) among the tested compounds.