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Short Paper | Regular issue | Vol 94, No. 7, 2017, pp.1314-1321
Published online, 8th June, 2017
DOI: 10.3987/COM-17-13711
Synthesis of Erlenmeyer-Plöchl Azlactones Promoted by 5-Sulfosalicylic Acid

Hamzeh Kiyani* and Shiva Aslanpour

*School of Chemistry, Damghan University, 36719-41167 Damghan, Iran

Abstract

5-Sulfosalicylic acid was found as an efficient catalyst in the synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones by condensation and cyclodehydration of aromatic aldehydes with hippuric acid and acetic anhydride at room temperature. The catalyst was easily recycled from the filtrate via evaporation of solvent and reused. This process is green, simple to handle, commercially available starting materials and catalyst, mild conditions, as well as it does not require to hazardous organic solvents, heating, and microwave and ultrasound irradiations.