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Paper | Regular issue | Vol 94, No. 7, 2017, pp.1257-1268
Published online, 6th June, 2017
DOI: 10.3987/COM-17-13712
Synthesis of N-Aryl-2-aminobenzoxazoles from Substituted Benzoxazole-2-thiol and 2-Chloro-N-arylacetamides in KOH-DMF System

Guang-cheng Wang,* Jing Wang, Lu-yao Li, Shan Chen, Ya-ping Peng, Zhen-zhen Xie, Ming Chen, Bing Deng, and Wen-biao Li

*College of Chemistry and Chemical Engineering, Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountains, Jishou University, Jishou 416000, China


A simple and novel method for the synthesis of N-aryl-2-aminobenzoxazoles from substituted benzoxazole-2-thiol and 2-chloro-N-arylacetamides in KOH-DMF system has been developed. The present protocol provides an attractive approach to access various N-aryl-2-aminobenzoxazoles in moderate to good yields without using transition metal catalyst under very mild reaction condition.