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Short Paper | Regular issue | Vol 94, No. 3, 2017, pp.531-540
Published online, 17th March, 2017
DOI: 10.3987/COM-17-13655
An Efficient and Multi-Component Synthesis of Functionalized Pyrazole Derivatives

Juxian Wang, Juanjuan Zhang, Yue Zhao, Guoning Zhang, Yucheng Wang,* and Daqing Shi*

*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China


A facile and efficient one-pot procedure for the synthesis of functionalized pyrazole derivatives via a four-component reaction of malononitrile, ethyl cyanoacetate, hydrazine hydrate and aldehydes under mild conditions in excellent yield is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization and chromatography purifications.