Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Short Paper | Regular issue | Vol 94, No. 3, 2017, pp.531-540
Published online, 17th March, 2017
DOI: 10.3987/COM-17-13655
An Efficient and Multi-Component Synthesis of Functionalized Pyrazole Derivatives

Juxian Wang, Juanjuan Zhang, Yue Zhao, Guoning Zhang, Yucheng Wang,* and Daqing Shi*

*College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, Jiangsu, China

Abstract

A facile and efficient one-pot procedure for the synthesis of functionalized pyrazole derivatives via a four-component reaction of malononitrile, ethyl cyanoacetate, hydrazine hydrate and aldehydes under mild conditions in excellent yield is described. This synthesis was confirmed to follow the group-assisted-purification (GAP) chemistry process, which can avoid traditional recrystallization and chromatography purifications.