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Short Paper | Regular issue | Vol 94, No. 8, 2017, pp.1567-1572
Published online, 9th June, 2017
DOI: 10.3987/COM-17-13690
One-Pot Four Component Reaction for the Synthesis of 1-(1H-Indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-dione Derivatives by Self-Catalysis

Faruq Mohammad* and Hamad A. Al-Lohedan

*Surfactant Research Chair, Department of Chemistry, King Saud University, P.O. Box 2455, Riyadh-11454, Saudi Arabia

Abstract

In this, we performed a four component domino reaction of phthaloyl dichloride, hydrazine hydrate, indole-3-carboxaldehydes and malononitrile/ethyl cyanoacetate to form 1-(1H-indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives by in situ generation of HCl as catalyst in refluxing ethanol for 1 h in good yields. This four component domino reaction transformation presumably proceeds via addition/dehydrohalogenation/condensation/cyclization of reactions. The material was thoroughly characterized at various stages of its formation by means of FTIR, NMR spectroscopic and Mass spectrometric analysis and is confirmed to be the derivative of 1-(1H-indol-2-yl)-1H-pyrazolo[1,2-b]phthalazine-5,10-dione.