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Paper | Regular issue | Vol 94, No. 3, 2017, pp.449-464
Published online, 17th March, 2017
DOI: 10.3987/COM-16-13641
Silver-Mediated Sulfenylation of Indoles and Benzimidazoles with Di(hetero)aryl Disulfides

Wen-Juan Wang and Xi-Cun Wang*

*Key Laboratory of Polymer Materials, College of Chemistry and Chemical Engineering, Northwest Normal University, Gansu 730070, China

Abstract

An efficient synthesis of novel sulfenylated N-heterocycles derivatives via AgNO3 mediated C–S coupling reaction has been developed. This reaction could be carried out under mild reaction conditions with straightforward operation and good yield. A wide range of substrates can be utilized for the C–S coupling reaction giving sulfenylated indoles and benzimidazoles, which are the importance of frameworks in medicinal and synthetic chemistry.