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Short Paper | Regular issue | Vol 94, No. 2, 2017, pp.326-333
Published online, 24th January, 2017
DOI: 10.3987/COM-16-13624
New Two Pebrolide Derivatives, 14-Deacetoxy-1-deoxypebrolide and 7’-Hydroxyasperphenamate Isolated from Penicillium sp. IFM62525

Syuhei Arai, Daigo Wakana, Takeshi Itabashi, Hisashi Takeda, Takashi Yaguchi, Galba Maria de Campos Takagi, and Tomoo Hosoe*

*Faculty of Pharmaceutical Sciences, Hoshi University, 2-4-41 Ebara, Shinagawa-ku, Tokyo 142-8501, Japan

Abstract

New two pebrolide type sesquiterpenoids, deacetoxy-1-deoxypebrolide (1) and 7’-hydroxyisoasperphenamate (2) along with asperphenamate (3), mycophenolic acid (4) and 1-deoxypebloride (5) were isolated from Penicillium sp. IFM 62525. Their structures were established from spectroscopic and chemical method. The absolute stereochemistry of 2 was confirmed by Marfey’s method. Antifungal activities of these compounds were tested and 4 showed strong activity.