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Short Paper | Regular issue | Vol 94, No. 1, 2017, pp.117-121
Published online, 20th December, 2016
DOI: 10.3987/COM-16-13599
A new Isocoumarin Derivative from an Endophytic Fungus Thielavia sp. Isolated from Crassula ovata

Ken-ichi Nakashima,* Junko Tomida, Takao Hirai, Yuji Morita, Yoshiaki Kawamura, and Makoto Inoue

*Laboratory of Medicinal Resources, Faculty of Pharmaceutical Sciences, Aichi Gakuin University, 1-100 Kusumoto-cho Chikusa-ku Nagoya city 464-8650, Japan

Abstract

Thielavic acid (1), a new isocoumarin derivative, was isolated from an endophytic fungus Thielavia sp. ECN-115, which was obtained from the stems of Crassula ovata. The relative structure of 1 was established by spectroscopic analyses including extensive 2D-NMR experiments. The absolute configuration was identified as (4S)-thielavic acid by comparing the experimental and calculated electronic circular dichroism spectra.