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Short Paper | Regular issue | Vol 94, No. 2, 2017, pp.297-307
Published online, 31st January, 2017
DOI: 10.3987/COM-16-13619
A One-Pot, Green Synthesis of Betti Base Containing Adenine Derivatives in Aqueous Medium

Dulin Kong, Zhongxiang Zhu, Jie Jiang, Luyong Wu, Xianghui Wang, Zaifeng Shi, Qiang Lin,* and Mingshu Wu*

*Chemical Engineering College, Nanjing University of Science & Technology, Nanjing, Jiangsu 210094, P. R. China
Key Laboratory of Tropical Medicinal Plant Chemistry of the Ministry of Education, College of Chemistry & Chemical Engineering, Hainan Normal University, Haikou 571158, P.R. China

Abstract

A one-pot, three-component condensation reaction of 2-naphthol, adenine and aliphatic or aromatic aldehydes in aqueous medium to give Betti base containing adenine derivatives in the presence of p-toluenesulfonic acid for the first time, is described. The present approach offers several advantages such as good yields, mild conditions (80 oC), clear reaction profile and simple work-up procedure. The entitled compounds are characterized by IR, NMR and HRMS.