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Short Paper | Regular issue | Vol 94, No. 1, 2017, pp.86-94
Published online, 2nd December, 2016
DOI: 10.3987/COM-16-13587
Efficient Construction of N-heterocycles from Benzylic Ethers/Alcohols and o-Substituted Anilines without Using any Catalyst and Additive

Xiuling Chen, Hongxue Qi, Shaofeng Wu, Leng Liu,* Jianhui Wen, Wanxi Li, Fang Guo, Yongjun Bian, and Jun Li*

*School of Chemistry & Chemical Engineering, Jinzhong Universityu, Shanxi Province Jinzhong University, 030600, China


A novel method for the synthesis of N-heterocycles from benzylic ethers/alcohols with o-substituted aniline without using any catalyst and additive is developed. This protocol involves C-O bond cleavage of benzylic ethers, N-benzylation, and benzylic C-H amidation in one pot, the tandem oxidation-cyclization transformation may open the door for the easy generation of N-heterocycles.