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Short Paper | Regular issue | Vol 92, No. 11, 2016, pp.2066-2077
Published online, 17th October, 2016
DOI: 10.3987/COM-16-13569
A Simplified Green Chemistry Approach to Synthesis of Azolo[1,5-a]pyrimidine Incorporated Thiophene Moiety

Tamer S. Saleh* and Abdullah S. Al-Bogami

*Green Chemistry Department, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt


A highly efficient and environmentally friendly protocol has been developed for a facile synthesis of novel azolo[1,5-a]pyrimidines incorporated thiophene moiety under microwave irradiation. The advantages of short reaction time, high efficiency, no separation of in situ generated intermediate, using cheap, non-corrosive sodium persulfate as the oxidant, together with a very simple work-up procedure, make this one-pot and solvent-free protocol a green and powerful alternative to traditional methods for the synthesis of these kinds of compounds.