Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact: purchase@heterocycles.com

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Review | Special issue | Vol 95, No. 1, 2017, pp.63-80
Published online, 14th February, 2017
DOI: 10.3987/REV-16-SR(S)1
Asymmetric Hydrogenation of Six-Membered Monocyclic N-Heteroaromatic Compounds

Atsuhiro Iimuro, Kosuke Higashida, Haruki Nagae, and Kazushi Mashima*

*Department of Chemistry, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka 560-8531, Japan

Abstract

Six-membered chiral cyclic amines are important skeletal structures found in natural products as well as bioactive species. Asymmetric hydrogenation of six-membered N-heteroaromatic compounds is considered one of the most straightforward protocols for preparing six-membered chiral cyclic amines, because asymmetric hydrogenation is an atom economical reaction and applicable to industrial scales. In this review, we summarize the development of asymmetric hydrogenation of six-membered N-heteroaromatic compounds, such as pyridines, pyrazines, pyrimidines, and pyridones.