Online article for Non-subscribers

Pay per view

Heterocycles has a pay-per-view service for Non-subscribers.
You will be able to directly purchase the full text article through PayPal.
Your purchased Paper can be downloaded after the payment is completed.
An e-mail will be sent the URL to download the paper.
If you have any questions, please contact:

Price: ¥ 4,400 (Yen only)
Period: This Article can be accessed for 7 days.

Paper | Regular issue | Vol 92, No. 10, 2016, pp.1822-1831
Published online, 6th September, 2016
DOI: 10.3987/COM-16-13557
Synthesis of Prodelphinidin Trimer Isolated from Cistus Albidus and its Growth Inhibitory Activity Against Human Prostate Cancer Cell Lines

Masataka Mori, Kiriko Matsumoto, Chisato Ishihara, Koichiro Kawaguchi, Sei-ichi Kawahara, Yasunao Hattori, Hiroshi Fujii,* and Hidefumi Makabe*

*Sciences of Functional Foods, Graduate School of Agriculture, Shinshu University, 8304 Minamiminowa-mura, Kamiina-gun, Nagano 399-4598, Japan


First synthesis of prodelphinidin trimer (epigallocatechin-gallocatechin-catechin) isolated from Cistus albidus was accomplished from monomeric epigallocatechin electrophile and dimeric gallocatechin-catechin nucleophile. The condensation was worked using AgOTf as a Lewis acid and condensed product was successfully converted into titled compound in good yield. Synthesized compound showed significant growth inhibitory activity against human prostate PC-3 cell lines. Its activity was little bit stronger than that of prodelphinidin B3.