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Review | Regular issue | Vol 92, No. 12, 2016, pp.2115-2140
Published online, 9th November, 2016
DOI: 10.3987/REV-16-848
Dipolar Cycloadditions of Nitrones in Aqueous Media

Giorgio Molteni*

*Department of Organic and Industrial Chemistry, University of Milano, Via Golgi 19, 20133 Milano, Italy

Abstract

1,3-Dipolar cycloadditions of nitrones in aqueous media have been recently exploited as a non-conventional protocol in the synthesis of the fully- or partly-saturated isoxazole ring. Water as the reaction medium can affect positively both cycloaddition rates and yields, while the large array of latent functionalities displayed by the cycloadducts is of interest in their further transformations. A systematic review of literature data is given; improvements with respect to the nitrone cycloaddition carried out in organic solvents will be taken into account.