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Paper | Regular issue | Vol 94, No. 2, 2017, pp.241-254
Published online, 31st January, 2017
DOI: 10.3987/COM-16-13543
The Reactivity of 4’-Substituted Spiro[Isoindole-1,3’-pyrazoles] Derivatives: Substitution/Elimination Reactions and Access to Biaryl Derivatives

Benedetta Maggio, Gianfranco Fontana, Maria Valeria Raimondi, Demetrio Raffa, Fabiana Plescia, Angela Maria Ingarra, and Giuseppe Daidone*

*STEBICEF, University of Palermo, Via Archirafi 32, 90123 Palermo, Italy

Abstract

This paper describes aspects of the chemistry of 4’-substituted spiro[isoindole-1,3’-pyrazoles]. These compounds underwent substitution and/or elimination reactions to afford some new spiro– as well as biaryl derivatives of potential pharmaceutical relevance. Mechanistic considerations are discussed as well.