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Paper | Regular issue | Vol 92, No. 11, 2016, pp.1976-1982
Published online, 5th October, 2016
DOI: 10.3987/COM-16-13533
Structure-Activity Relationship of Phenylethanoid Glycosides on the Inhibition of Amyloid β Aggregation

Eri Kidachi, Manami Kurisu, Yusaku Miyamae, Mizuho Hanaki, Kazuma Murakami, Kazuhiro Irie, and Hideyuki Shigemori*

*Graduate School of Life and Environmental Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba, Japan


The structure-activity relationship of the inhibitory activity of Aβ aggregation and antioxidant activity for phenylethanoid glycosides, acteoside (1), oraposide (2), and their derivatives which isolated from Orobanche minor was investigated. Acteoside (1) and oraposide (2) containing two catechol moieties exhibit strong activities for inhibition of Aβ aggregation and antioxidant. These results suggested that existence of the catechol moieties of the phenylethanoid glycosides were important roles for these activities.