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Short Paper | Regular issue | Vol 92, No. 10, 2016, pp.1857-1863
Published online, 22nd August, 2016
DOI: 10.3987/COM-16-13513
Three New Phenylpropanoids from the Leaves of Yunnan Local Sun Cured Tobacco and Their Bioactivities

Feng-Mei Zhang, Jian-Jun Xia, Pei-Song Yang, Qin-Peng Shen, Chun-Bo Liu, Pei He, Jia-Qiang Wang, Zhi-Hua Liu,* and Zhong-Tao Ding*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China


Three new benzolactones, 5-(hydroxymethyl)-6-(2-oxopropyl)isobenzofuran-1(3H)-one (1), 5-methyl-6-(2-oxopropyl)isobenzofuran-1(3H)-one (2), and 5-methoxy-6-(2-oxopropyl)isobenzofuran-1(3H)-one (3), together with three known benzolactones (4-6) were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-3 were tested for their anti-tobacoo mosaic virus (TMV) activities and compounds 1-6 were tested for their cytotoxicity activities. The results revealed that compound 1-3 showed high anti-TMV activity with inhibition rate of 28.6, 31.2 and 32.7%. These rates are close to that of positive control. Compounds 1-6 also showed moderate-to-weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.5-8.5 μM.