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Obituary
Yoshito Kishi (1937-2023)
Yoshito Kishi (1937-2023)
Professor. Yoshito Kishi,
a member of the Honorary Editorial Associates of HETEROCYCLES,
has passed away on January 9, 2023 at the age of 85.
I deeply express my regret over his death.
Kunio Ogasawara
Editor
January 13, 2023
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Short Paper | Regular issue | Vol 92, No. 9, 2016, pp.1706-1712
Published online, 19th July, 2016
Published online, 19th July, 2016
DOI: 10.3987/COM-16-13511
■ Two New Alkaloids from the Seeds of Cassia alata and Their Bioactivities
Pei-Song Yang, Wei Zhang, Xiao-Feng Shen, Xin-Lin Wang, Chao Li, Xiao-Wei Gong, Xu-Dong Zheng, Dong-Lai Zhu,* and Jia-Qiang Wang*
*School of Chemical Science and Technology, Yunnan University, Kunming 650091, China
Abstract
Two new alkaloids, 6-(hydroxymethyl)-3,9-dimethyl-7H-benzo[de]quinolin-7-one (1) and 6-(hydroxymethyl)-8-methoxy-3,9-dimethyl-7H-benzo[de]quinolin-7-one (2), together with four known alkaloids (3-6) were isolated from the seeds of Cassia alata. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (TMV) activities, and the results showed that compound 2 exhibited high anti-TMV activity with inhibition rates of 38.5%. This rate is higher than that of the positive control. The cytotoxicities of compounds 1-6 against five human tumor cell lines (NB4, A549, SHSY5Y, PC3 and MCF7) were also tested. Compounds 1-6 showed weak inhibitory activities against some tested human tumor cell lines with IC50 values in the range of 2.5-7.5 μM.
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