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Short Paper | Regular issue | Vol 92, No. 10, 2016, pp.1833-1856
Published online, 5th September, 2016
DOI: 10.3987/COM-16-13512
Thiosemicarbazides, Potent Reagents for Synthesis of Some New 1,4-Diphenylbenzo[g]quinoxaline-5,10-dione Based Heterocycles

Islam H. El Azab* and Hosam A. Saad

*Department of Chemistry, Faculty of Science, Aswan University, Aswan 81528, Egypt

Abstract

2-(5,10-Dioxo-1,4-diphenyl-3,4-dihydrobenzo[g]quinoxalin-2(1H,5H, 10H)-ylidene)hydrazinecarbothioamide (4) and 2-((4-oxothiazolidin-2-ylidene)- hydrazono)-1,4-diphenyl-1,2,3,4-tetrahydrobenzo[g]quinoxaline-5,10-dione (5), were prepared and utilized as versatile building blocks, via incorporating in series of conversions including cyclocondensation reactions to afford a series of four and fivepharmacophoricmotif conjugates 10, 13, 18, 20, 21, 25, 30, 31, 32, 33 and 34 in fair yields.