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Paper | Special issue | Vol 95, No. 2, 2017, pp.799-806
Published online, 19th December, 2016
DOI: 10.3987/COM-16-S(S)45
Stylissamide I, a New Cyclic Heptapeptide from an Okinawan Marine Sponge Stylissa sp.

Takaaki Kubota,* Kenta Nakamura, Shin-ichiro Kurimoto, Kanae Sakai, Jane Fromont, Tohru Gonoi, and Jun'ichi Kobayashi*

*Showa Pharmaceutical University, 3-3165 Higashi-Tamagawagakuen, Machida, Tokyo 194-8543, Japan


A new cyclic heptapeptide, stylissamide I (1), was isolated from an Okinawan marine sponge Stylissa sp. The structure of stylissamide I (1) was elucidated to be cyclo-(L-Tyr1-L-Tyr2-L-Tyr3-L-Pro1-L-Pro2-L-Val-L-Pro3) by extensive spectral analyses and Marfey’s method. Stylissamide I (1) showed antifungal activity against Aspergillus niger.