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Review | Special issue | Vol 95, No. 2, 2017, pp.694-714
Published online, 30th January, 2017
DOI: 10.3987/REV-16-SR(S)6
Synthetic Methods for Ring-Fluorinated Pyrrole Derivatives

Takeshi Fujita and Junji Ichikawa*

*Division of Chemistry, Faculty of Pure and Applied Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8571, Japan


The synthesis of pyrrole ring-fluorinated heterocyclic compounds has been increasingly studied in response to the rising demand for these compounds as potential drugs, agrochemicals, and advanced materials. The approaches to their synthesis are grouped into two categories in terms of how the fluorine substituents are introduced: (i) direct fluorination of the existing pyrrole and related rings and (ii) the construction of pyrrole rings via fluorine-containing precursors. This review overviews recent synthetic methods for ring-fluorinated pyrrole derivatives according to the types of reactions.