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Communication | Special issue | Vol 95, No. 1, 2017, pp.172-180
Published online, 13th December, 2016
DOI: 10.3987/COM-16-S(S)47
Gold(III)-Catalyzed Synthesis of 2,3,4-Trisubstituted Dihydropyrans from Propargylic Alcohols with 1,3-Dicarbonyl Compounds

Nobuyoshi Morita,* Kazuki Oguro, Saori Takahashi, Midori Kawahara, Shintaro Ban, Yoshimitsu Hashimoto, and Osamu Tamura*

*Showa Pharmaceutical University, Machida, Tokyo 194-8543, Japan

Abstract

2,3,4-Trisubstituted dihydropyrans were efficiently synthesized by tandem reaction of propargylic alcohols with 1,3-dicarbonyl compounds in the presence of 5 mol% gold(III) catalyst (dichloro[2-pyridinecarboxylato]gold) and 10 mol% silver catalyst (AgNTf2).