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Paper | Special issue | Vol 95, No. 1, 2017, pp.462-473
Published online, 7th December, 2016
DOI: 10.3987/COM-16-S(S)37
Synthesis of Photophore and Fluorophore Modified O-Benzylserine Derivatives

Makoto Hashimoto,* Takuma Yoshida, Zetryana Puteri Tachrim, Yasuko Sakihama, Yasuyuki Hashidoko, Yasumaru Hatanaka, and Yuichi Kanaoka

*Graduate School of Agriculture, Hokkaido University, Kita 9 Nishi 9, Kita-ku, Sapporo, Hokkaido 060-8589, Japan

Abstract

O-Benzylation of serine is one of the important protection methods for solid phase peptide synthesis. The utilities of the protection group may be indicated that chemical modifications for O-benzylserine will be utilized to make functional peptides on solid phase synthesis. Detailed studies for effective synthesis of photoreactive and fluorophore containing O-benzylserine derivatives without racemization were reported.