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Paper | Special issue | Vol 95, No. 1, 2017, pp.445-461
Published online, 17th February, 2017
DOI: 10.3987/COM-16-S(S)36
8-Methyl Derivatives of Aristeromycin, Neplanocin, 3-Deazaneplanocin and Related Analogs

Xueqiang Yin, Qi Chen, Wei Ye, Chong Li, and Stewart W. Schneller*

*Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University, Auburn, Alabama 36849-5312, U.S.A.

Abstract

The promising biological properties of 8-methyladenosine prompted a study of the related carbocyclic analogs based on aristeromycin and neplanocin. These target compounds have been prepared from strategically protected parent carbocyclic nucleoside derivatives or built up from suitable cyclopentanols and cyclopentenols. Several of these nucleosides were evaluated against a variety of RNA and DNA viruses to determine the potential of the 8-methyl series as a source for new antiviral agents. Encouraging results towards Epstein-Barr virus, cowpox, vaccinia virus, Ebola, and the flaviviruses (dengue and yellow fever) suggests more extensive studies.