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Paper | Special issue | Vol 95, No. 1, 2017, pp.304-313
Published online, 18th October, 2016
DOI: 10.3987/COM-16-S(S)19
Synthesis of Enantioenriched Indolopiperazinones via Iridium(I) N-Heterocyclic Carbene Complex Catalyzed Asymmetric Intramolecular Allylic Amination Reaction

Ke-Yin Ye, Ke-Jia Wu, Guo-Tai Li, Li-Xin Dai, and Shu-Li You*

*State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 345 Lingling Road, Shanghai 200032, China


Systematic study on employing the D-camphor derived carbenes as the chiral ligands in iridium-catalyzed intramolecular allylic amination reaction was carried out. Under mild reaction conditions, enantioenriched indolopiperazinones were obtained in good yields (75-95%) and high enantioselectivity (88-94% ee).