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Paper | Special issue | Vol 95, No. 1, 2017, pp.187-199
Published online, 2nd June, 2016
DOI: 10.3987/COM-16-S(S)2
Synthetic Study towards Construction of Potential Scaffold of Antitumor Agents Andrastins

Shuqiang Yin, Kenji Sugimoto, Hideo Nemoto, and Yuji Matsuya*

*Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, Sugitani 2630, Toyama, 930-0194, Japan


For a construction of potential scaffold of antitumor agents andrastins, intramolecular Diels-Alder reaction of the triene composed of trans-fused AB ring with tethered D ring was examined. The reaction in refluxing toluene afforded a desired cis-fused hydrindane skeleton, the relative stereochemistries of which were unambiguously determined by X-ray crystallographic analysis.