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Review | Special issue | Vol 95, No. 1, 2017, pp.116-126
Published online, 5th December, 2016
DOI: 10.3987/REV-16-SR(S)3
Total Synthesis of (+)-Linoxepin

Minami Odagi,* Kota Furukori, Yoshiharu Yamamoto, and Kazuo Nagasawa*

*Department of Biotechnology and Life Science, Faculty of Technology, Tokyo University of Agriculture and Technology, Koganei, Tokyo 184-8588, Japan


(+)–Linoxepin is a lignan-type natural product with a synthetically challenging fused dihydronaphthalene/dihydroxepine structure. It also has multiple biological activities, including antitumor, antioxidant, and antiviral activities. Here, we review three recent total syntheses of (+)–linoxepin.