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Communication | Special issue | Vol 95, No. 2, 2017, pp.748-752
Published online, 24th January, 2017
DOI: 10.3987/COM-16-S(S)77
■ Chemistry of Renieramycins. 16. Structure of 7-Desmethylrenieramycin O (= 14α-Hydroxyrenieramycin S) from Blue Sponge, Xestospongia sp.

Naoki Saito,* Ai Hiramatsu, Hiromi Hirade, Mitsue Kubota, Ryoko Toyoshima, Akiya Fujino, Natchanun Sirimangkalakitti, Khanit Suwanborirux,* and Gisela P. Concepcion

*Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2-522-1 Noshio, Kiyose, Tokyo 204-8588, Japan

Abstract

A new renieramycin-type marine natural product was isolated from the blue sponge Xestospongia sp. found in the Philippines and Thailand, and its structure was elucidated to be 7-demethylrenieramycin O (= 14α-hydroxyrenieramycin S, 1) by comparing its spectral data with those of renieramycins O and S. Exposure of a dichloromethane solution of renieramycin O to sunlight gave compound 1 along with renieramycin U. Compound 1 showed weak cytotoxicity to several human cancer cell lines.