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Paper | Special issue | Vol 95, No. 2, 2017, pp.1121-1131
Published online, 14th February, 2017
DOI: 10.3987/COM-16-S(S)83
Catalytic Intramolecular [2+2+2] Cycloaddition of Peptide-Tethered Branched Triynes for the Synthesis of Cyclic Peptides

Shuhei Obinata, Yu-ki Tahara, Kyalo Stephen Kanyiva, and Takanori Shibata*

*Department of Chemistry and Biochemistry, School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku, Tokyo 169-8555, Japan


Rhodium-catalyzed intramolecular [2+2+2] cycloaddition of peptide-tethered branched triynes gave cyclic peptides in moderate to excellent yields. This is a new catalytic protocol for the synthesis of cyclic peptides containing various amino acids.