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Short Paper | Regular issue | Vol 92, No. 7, 2016, pp.1293-1306
Published online, 19th May, 2016
DOI: 10.3987/COM-16-13476
Synthesis and DNA Cleavage Activity of Functionalized Pyrazol-3-ones Containing Oxime Ester

Eiichi Masumoto, Nobuhiro Kashige, Fumi Okabe, Fumio Miake, Kenji Yamagata, and Hiroshi Maruoka*

*Faculty of Pharmaceutical Sciences, Fukuoka University, 8-19-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan

Abstract

A facile access to the synthesis of functionalized pyrazol-3-ones containing oxime ester from 4-hydroxypyrazol-3-ones, which were prepared starting from 4-alkylidenepyrazol-3-one, in moderate to good yields is reported. The structures of all products were identified by spectral data and some synthesized compounds were tested for their DNA cleavage activity.