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Short Paper | Regular issue | Vol 92, No. 7, 2016, pp.1282-1292
Published online, 25th May, 2016
DOI: 10.3987/COM-16-13471
Design and Synthesis of Benzothiazole Schiff Bases of Potential Antitumor Activitiy

Thuraya Al-Harthy, Raid Abdel-Jalil,* Wajdi Zoghaib, Maren Pflüger, Elisabeth Hofmann, and Harald Hundsberger

*Department of Chemistry, Sultan Qaboos University, P.O.Box 36 Al-Khoud 123, Oman

Abstract

In an attempt to develop a new class of selective antitumor agents, a novel series of benzothiazole derivatives was prepared via the condensation of 5-fluoro-6-(4-methylpiperazin-1-yl)benzo[d]thiazol-2-amine with aromatic aldehydes. The preliminary bioassay reveals that (4-fluorobenzylidene)-[5-fluoro-6-(4-methylpiperazin-1-yl)-benzothiazol-2-yl]-amine show specific anticancer cytotoxicity.