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Short Paper | Regular issue | Vol 92, No. 7, 2016, pp.1261-1271
Published online, 25th May, 2016
DOI: 10.3987/COM-16-13461
Synthesis, Biological Evaluation of Some New Thiophene Derivatives

Sraa Abu-Melha*

*Department of Chemistry, Faculty of Science of Girls, King Khaled University, Abha 00966, Saudi Arabia


The reaction of 2-pyridylacetophenone (2) with phenyl isothiocyanate gave thiocarbamoyl derivative 4 which on reaction with α-halocarbonyl compounds in a mixture of ethanol and N,N-dimethylformamide in the presence of triethylamine afforded thiophenes 6, 8, 10, 12 and 14 derivatives. While, when the same reaction was carried out in ethanol without N,N-dimethylformamide, it afforded the corresponding acyclic compounds 5, 7, 9, 11 and 13 which on reflux in N,N-dimethylformamide in the presence of triethylamine gave the corresponding thiophene derivatives. The newly synthesized compounds were characterized by analytical, spectral data and evaluated their antimicrobial activities. Compounds 6, 8, 10, 12, 13 and 14 were found to have high antimicrobial activities.