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Short Paper | Regular issue | Vol 92, No. 7, 2016, pp.1245-1260
Published online, 24th May, 2016
DOI: 10.3987/COM-16-13455
Synthesis of Quercetin Glycosides and Their α-Glucosidase Inhibitory Activities

Bixue Xu,* Guangyi Liang,* Zhonghang Wen, Zhanxin Hu, Jie Yuan, Hongju Chen, and Limei Zhang

*The Key Laboratory of Chemistry for Natural Products of Guizhou province and Chinese Academy of Sciences, Guiyang 550002, Guizhou, China

Abstract

A series of quercetin glycosides as the analogues of 3,5,5'-trimethyl-7-O-β-D-glucopyranosylquercetin (8) were synthesized, their structures were confirmed by 1H NMR, 13C NMR and MS. The inhibitory activities of those compounds against α-glucosidase were evaluated in vitro, in particular, the compounds V-c and V-d-2 showed promising bioactivities with IC50 of 19.4 μmol·L–1 and 19.7 μmol·L–1, are much higher than 8 (IC50 > 100 μmol·L–1). This research will provide a reference in the study of the synthetic methods and hypoglycemic activity for the quercetin glycosides.