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Short Paper | Regular issue | Vol 92, No. 3, 2016, pp.560-572
Published online, 4th February, 2016
DOI: 10.3987/COM-15-13398
Room-Temperature One-Pot Palladium-Catalyzed Synthesis of 3-Hydroxyisoindolin-1-ones from Phenylglyoxylic Acids

Menglei Yuan, Yu Sun, Hui Yan, Jinxiong Wu, Gaofeng Ma, Feng Li, Siyu Miao, Mengyao Hao, and Na Li*

*Department of Chemical Engineering & Process, North University of China, Changning Road 65, Shuozhou, Shanxi, 036000, China


A room-temperature and efficient synthesis of 3-hydroxyisoindolin-1-ones by Pd-catalyzed C-H activation has been proposed. Wide ranges of benzamides and phenylglyoxylic acids indicated good functional group tolerance and wide potential application of this approach. Moreover, good yields of products further made it practical and attractive.