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Short Paper | Regular issue | Vol 92, No. 2, 2016, pp.353-360
Published online, 14th January, 2016
DOI: 10.3987/COM-15-13386
Inhibition of NF-κB and Cellular Invasion by Novel Flavonoid Dismal in Ovarian Carcinoma Cells

Liyan Wang, Yinzhi Lin, Kulrawee Sidthipong, Jianqiang Tang, Mengjie Li, Takashi Koyano, Thaworn Kowithayakorn, Kengo Sumiyoshi, Tamami Ukaji, and Kazuo Umezawa*

*Molecular Target Medicine, School of Medicine, Aichi Medical university, 1-1 Yazako-Karimata, Nagakute-shi, Aichi 480-1195, Japan


In the course of our screening of NF-κB inhibitors, we isolated known flavonoids that inhibit LPS-induced NO production in mouse monocytic leukemia RAW264.7 cells. Since those flavonoids inhibited the NF-κB activity, we have evaluated the inhibitory activity of plant-derived novel flavonoid, desmal, on NF-κB, and found that it inhibits LPS-induced NO production and NF-κB. It also inhibited cellular invasion possibly by the decrease of NF-κB-dependent urokinase-type plasminogen activator. Thus, desmal was found to be a new NF-κB inhibitor having cellular anti-inflammatory and anti-metastatic activities.