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Short Paper | Regular issue | Vol 92, No. 1, 2016, pp.133-140
Published online, 11th December, 2015
DOI: 10.3987/COM-15-13364
An Efficient One-Pot Synthesis of Azuleno[2,1-b]pyridazines

Dao-Lin Wang,* Jian Ma, Xiao-Ce Shi, and Jian-Ying Wu

*Liaoning Key Laboratory of Synthesis and Application of Functional Compound, College of Chemistry & Chemical Engineering, Bohai University, Jinzhou 121001, China


A simple and efficient procedure was developed for the synthesis of 1-aryl-3-cyano-4-oxo-10-ethoxycarbonylazuleno[2,1-b]pyridazines (3) in good yields by condensation of ethyl 1-cyanoacetyl-2-methoxyazulene-3-carboxylate (1) with aryldiazonium salt (2) in pyridine via a domino reaction. This reaction provides a new procedure for synthesis of heterocyle-fused azulenes.