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Short Paper | Regular issue | Vol 92, No. 1, 2016, pp.114-119
Published online, 18th December, 2015
DOI: 10.3987/COM-15-13361
Isoquinoline Alkaloids from the Twigs of Cassia fistula and Their Anti-Tobacco Mosaic Virus Activity

Hai-Yan Wu, Qiang Liu, Zhen-Hua Yu, Wei-Yao Hu, Ke-Liang Yan, Ye-De Wang, Kun Zhou, Wei Dong, Min Zhou,* and Qiu-Fen Hu*

*Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming, Jingming South Road, Chenggong New District, Kunming, Yunnan 650500, China


Two isoquinoline alkaloids, including a new natural product (1) and a compound (2) isolated from plant for the first time, and named fistulatins A and B (1 and 2), together with four known isoquinoline alkaloids (3-6) were isolated from the twigs of Cassia fistula. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1-6 were tested for their anti-tobacco mosaic virus (anti-TMV) activity. The results showed that all isolates showed weak anti-TMV activity with inhibition rates in the range of 15.4-23.5%.