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■ An Efficient Conversion of Lysine to 2-Aminocaprolactam

Hiroshi Matsumoto, Kouji Kaiso, and Akio Kamimura*

*Department of Applied Molecular Bioscience, Graduate School of Medicine, Yamaguchi University, , Japan

Abstract

Treatment of lysine in wet MeOH at high-temperatures provided a smooth and efficient conversion to 2-aminocaprolactam that is recognized as a potential intermediate for the preparation of bioactive compounds. The obtained 2-aminocaprolactam underwent very rapid racemization under these conditions. A kinetic study of the reaction was performed.