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Short Paper | Regular issue | Vol 92, No. 3, 2016, pp.511-520
Published online, 4th February, 2016
Published online, 4th February, 2016
DOI: 10.3987/COM-15-13342
■ Synthesis and Biological Evaluation of Novel Coumarin Derivatives as Antiplatelet Agents
Peng Huang, Lei-Lei Gao, Zhuo Zhang, Jing-Ru Liu, and Li-Qin He*
*School of Pharmacy, Anhui University of Chinese Medicine, Yaohai District of Hefei City, Anhui Province, Mo Dian Xiang Anhui University of Chinese medicine shaoquan Lake Campus, 230012, China
Abstract
In order to develop anti-thrombotic agents with higher potency, a series of novel coumarin derivatives (5a-m) were designed, synthesized and biologically evaluated. Compound 5e displayed the strongest activity in inhibiting the adenosine diphosphate (ADP)-induced platelet aggregation in vitro, with 2.3-fold more effectiveness than clinically used antiplatelet drug aspirin (ASP). Thus, Compound 5e could deserve further investigations as antiplatelet agents.
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