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Short Paper | Regular issue | Vol 92, No. 2, 2016, pp.346-352
Published online, 24th December, 2015
DOI: 10.3987/COM-15-13362
Cytotoxic Compounds from Scolopendra subspinipes mutilans

Yu-Ming Liu,* Jian-Bing Nie, Lin-Na Sun, and Qing-Hua Liu

*Department of Pharmacy Engineering, Tianjin University of Technology, No.391, Bin Shui Xi Road, Xi Qing District, Tianjin , China


A new amino acid, 2S-3-(1-methyl-1H-imidazol-5-yl)-2- (methylamino)propanoic acid (1) and a new natural product, 3, 5-dihydroxyquinoline (2), along with a known compound (3) were isolated from the centipede Scolopendra subspinipes mutilans L. Koch. Their structures were elucidated on the basis of extensive one-dimensional (1D)- and 2D-NMR spectroscopic analyses and mass spectrometry. All isolates were evaluated for their cytotoxic activities against three human cancer cell lines, HepG-2, HT-29, and A549. Compounds 2 and 3 exhibited moderate cytotoxic activities with IC50 values of 1.95–27.20 μM against the three cancer cell lines.