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Short Paper | Regular issue | Vol 92, No. 2, 2016, pp.331-336
Published online, 25th December, 2015
DOI: 10.3987/COM-15-13331
■ Two New Isoindolin-1-ones from the Leaves of Nicotiana tabacum and Their Anti-Tobacco Mosaic Virus Activities

Guang-Hui Kong, Yu-Ping Wu, Wei Li, Zhen-Yuan Xia, Qiang Liu, Kun-Miao Wang, Pei He, Rui-Zhi Zhu, Xiao-Xi Si, and Guang-Yu Yang*

*Key Laboratory of Tobacco Chemistry of Yunnan Province, China Tobacco Yunnan Industry Company, Hongjin Road 181#, Kunming, 650231, China

Abstract

Two new isoindolin-1-ones, 2-(2-hydroxyethyl)-5-methyl-6-(3- methylbut-2-enyl)isoindolin-1-one (1) and 2,5-dimethyl-6-(3-methylbut-2-enyl) isoindolin-1-one (2), were isolated from the leaves of Nicotiana tabacum. Their structures were determined by means of HRESIMS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacco mosaic virus (anti-TMV) activities. The results revealed that compounds 1 and 2 showed potential anti-TMV activities with inhibition rates of 48.2 and 45.6%, respectively.